Faktor-faktor yang berpengaruh terhadap kematian akibat penyakit paru obstruktif kronis eksaserbasi akut di Rumah Sakit Ngoerah
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Chronic obstructive pulmonary disease (COPD) acute exacerbation is a period of worsening of a previous condition that affects the patient's clinical outcome. Its prevalence in the Asia-Pacific region reaches 46%. The purpose of this study was to determine the relationship between smoking history, exacerbation history, hospital admission history and baseline SaO2 factors with mortality due to acute exacerbation of COPD at Ngoerah Hospital. Methods: This study is an analytical case control study with a sample size of 48 cases and controls each groups. The data collection technique uses the total sampling method. Results: The study sample was dominated by men (62.5%), normal body mass index (BMI) (74%), low baseline SaO2 characteristics <92% (63.5%), history of hospitalization (86.5%), smoking history (55.2%), history of exacerbation (43.8%), and suffering from respiratory tract infection (77.1%). There was a significant relationship between baseline SaO2 and death (OR 5.12; 95% CI 2.03 - 12.83; p <0.05), history of exacerbation and death (OR 4.11; 95% CI 1.73 - 9.71; p <0.05). There was a non-significant relationship between history of hospital admission and death (OR 1.72; CI 95% 0.51 – 5.69; p >0.05), history of smoking and death (OR 1.08; CI 95% 0.48 – 2.43; p >0.05). Conclusion: There is a relationship between baseline SaO2 and history of exacerbation with death. However, there is no significant relationship between smoking history, history of hospitalization, and baseline SaO2 with death due to acute exacerbation of COPD at Ngoerah Hospital. Latar Belakang: Penyakit paru obstruktif kronis (PPOK) eksaserbasi akut merupakan periode perburukan dari kondisi sebelumnya yang memengaruhi luaran klinis pasien. Prevalensinya pada kawasan Asia-Pasifik mencapai 46%. Tujuan dari penelitian ini untuk mengetahui hubungan faktor riwayat merokok, riwayat eksaserbasi, riwayat masuk rumah sakit dan baseline SaO2 terhadap kematian akibat PPOK eksaserbasi akut di Rumah Sakit Ngoerah. Metode: Penelitian ini adalah studi case control analitik dengan jumlah sampel pada kelompok kasus dan kontrol masing-masing sebanyak 48 sampel. Teknik pengumpulan data menggunakan metode total sampling. Hasil: Sampel penelitian didominasi oleh laki-laki (62,5%), indeks massa tubuh (IMT) normal (74%), karakteristik baseline SaO2 rendah <92% (63,5%), riwayat masuk rumah sakit (86,5%), riwayat merokok (55,2%), riwayat eksaserbasi (43,8%), dan menderita infeksi saluran pernapasan (77,1%). Didapatkan hubungan yang bermakna antara baseline SaO2 dan kematian (OR 5,12; CI 95% 2,03 – 12,83; p <0,05), riwayat eksaserbasi dan kematian (OR 4,11; CI 95% 1,73 – 9,71; p <0,05). Didapatkan hubungan yang tidak bermakna antara riwayat masuk rumah sakit dan kematian (OR 1,72; CI 95% 0,51 – 5,69; p >0,05), riwayat merokok dan kematian (OR 1,08; CI 95% 0,48 – 2,43; p >0,05). Simpulan: Terdapat hubungan antara baseline SaO2 dan riwayat eksaserbasi dengan kematian. Namun, tidak terdapat hubungan yang signifikan antara riwayat merokok, riwayat masuk rumah sakit, dan baseline SaO2 dengan kematian akibat PPOK eksaserbasi akut di Rumah Sakit Ngoerah.
Source: Intisari Sains Medis
Institution: Udayana University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414837595
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