Work

Identification of upregulated genes in pulmonary hypertension using RNA sequencing profiling

Year: 2025

Type: article

Abstract: Pulmonary hypertension (PH) is a chronic and progressive disease that is characterized by increased pulmonary arterial blood pressure, causing heart strain and eventual heart failure. In the current study PH RNA sequencing (RNA-Seq) dataset involving 8 patients, consisting of 4 cases and 4 controls was selected for analysis. Pathway analysis revealed the involvement of the key genes in pathways crucial for PH. The protein-protein interaction (PPI) network analysis using the STRING database identified key hub genes that were significantly upregulated, including HAUS4, TUBB4A, TUBG1, NEED1, SASS6, NIN, DCUN1D3, CCDC22, ATP2B2 and LRRC37A. These hub gene-encoded proteins can be prominent drug targets for future interventions aimed at treating pulmonary hypertension.

Source: Bioinformation

DOI: 10.6026/973206300213105

Authors: Jino Blessy J, Jayasurya R, Shanmugapriya Murugan, Shirley Lois G

Institution: Sri Ramachandra Institute of Higher Education and Research

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414842185