Work

Comparison of salivary carcino embryonic antigen among tobacco users without lesions, oral potentially malignant disorders and oral squamous cell carcinoma

Year: 2025

Type: article

Abstract: Oral cancer, mainly oral squamous cell carcinoma (OSCC), is a common head and neck malignancy affecting multiple oral sites. This study compared salivary carcinoembryonic antigen (CEA) levels among tobacco users without lesions, patients with oral potentially malignant disorders (OPMDs), and OSCC patients. Thirty subjects were divided into three groups of ten, and unstimulated saliva samples were collected and analyzed using a Can Ag Diagnostics ELISA kit. Data analysis was performed using SPSS v26, with means compared by one-way ANOVA and t-tests. Results showed CEA levels were highest in OSCC, followed by OPMDs and tobacco users, suggesting its role as a non-invasive biomarker for early malignant transformation.

Source: Bioinformation

DOI: 10.6026/973206300213239

Authors: Padmanathan Renganathan, Harsha Vardhan B. G, Srividhya Srinivasan, Saraswathi Gopal K

Institutions: Meenakshi Academy of Higher Education and Research, Meenakshi Ammal Dental College and Hospital

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414845439