Year: 2025
Type: article
Abstract: This review discusses multi-omics (genomic, transcriptomic, and proteomic) approaches for studying bacteria of the Bacteroides spp. group, which are the most common anaerobes in the human colon and are responsible for over half of all intra-abdominal anaerobic infections. These multi-omics approaches have enabled the identification of virulence factors, antimicrobial resistance genes, and other functional elements of the Bacteroides genome. This information is crucial for understanding the pathogenic potential of these bacteria and their role in the development of anaerobic infections. This review examines the transcriptional response of Bacteroides after exposure to sub-inhibitory concentrations of antimicrobial drugs, as well as the main methods of proteomic analysis and achievements in studying the Bacteroides proteome. Overall, the modern perspectives of multi-omics studies on Bacteroides emphasize the possibility of integrating different omics approaches for a more comprehensive understanding of their biology, functional characteristics, and ecological roles in the gut ecosystem.
Source: Journal of biological research.
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Award: G8731044899
OpenAlex ID: W4414850030
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