Year: 2025
Type: article
Abstract: IFN-γ, a key player in the pathogenesis of deep vein thrombosis (DVT), acts as a bridge between immune responses and coagulation activation. It promotes endothelial activation, leukocyte recruitment, cytokine release, and coagulation imbalance. This critical pro-inflammatory and prothrombotic role makes IFN-γ a promising molecular target in DVT management beyond traditional anticoagulation methods. Exploring pharmacological inhibition of IFN-γ signaling or its downstream effectors could open new therapeutic pathways for DVT, enhancing resolution and averting post-thrombotic complications. This review summarizes pathophysiology, diagnostics, and management of DVT, and adds further information on the role of IFN-γ as a key cytokine to target to advance DVT therapeutics.
Source: Immuno
Author: Kawaljit Kaur
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,207
OpenAlex ID: W4414853379