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Gamma‐Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug‐Induced Immunosuppression (Adv. Sci. 37/2025)

Year: 2025

Type: article

Abstract: Gamma-Glutamyl Cysteine Ligase GLed is a reversible europium-based sensor for glutathione that allows real-time, single-cell tracking of Gamma-Glutamyl Cysteine Ligase (GCL) activity, a function still not fully understood in human T cells. GLed directly links GCL activity to T cell effector functions, revealing that GCL is a critical regulator and a potential therapeutic target for immune-related diseases. More details can be found in article number 2501179 by Francisco Fueyo-González, Miguel Fribourg, Juan A. González-Vera, and co-workers. Cover artwork by M. Eugenio Vázquez.

Source: Advanced Science

DOI: 10.1002/advs.71805

Authors: Francisco Fueyo‐González, Carmen Salto‐Giron, Mehek Ningoo, Laura Espinar‐Barranco, Rafael Salto, Jose Manuel Paredes, Rosario Herranz, Angel Orte, Miguel Fribourg, Juan A. González‐Vera

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730

OpenAlex ID: W4414855063

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