Methionine restriction and mimetics to ameliorate human aging and disease
Year: 2025
Type: review
Abstract: Methionine restriction (MetR) attenuates the severity of numerous age-related diseases and extends lifespan across multiple species. Implementing MetR in humans remains challenging due to the low palatability of MetR diets, unfavorable side effects associated with continuous dietary MetR, and interindividual variation in factors that can diminish its efficacy, including microbiota activity, compensatory effects from cysteine, and methionine transfer from neighboring cells. Several novel approaches that target methionine metabolism have been developed - including small molecules, synthetic biotics, and xenotopic tools - with some already translated into early-stage clinical trials. In this review, we discuss a variety of approaches that either produce or mimic MetR, as well as their potential applications for human healthspan improvement.
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
Awards: Metabolomics clocks as a tool to explore mechanisms of aging, Pittsburgh Older Americans Independence Center, Beneficial reprogramming of lipid metabolism with intermittent fasting, Combined targeting of synthetic lethal partners in RB1-deficient cells, Dissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and Atherosclerosis, Methionine Cycle as a Mechanistic Hub for the Hallmarks of Aging, Deciphering the crosstalk between methionine metabolism and methyltransferases in health and disease
OpenAlex ID: W4414860670