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Cross-sectional analysis of gut microbiome diversity with progression of Alzheimer's disease

Year: 2025

Type: article

Abstract: The relationship between gut microbiome diversity and stages of Alzheimer's disease (AD) progression is of interest. Hence, a total of 124 participants, including cognitively normal controls and patients with mild, moderate, and severe AD, were assessed for microbiome composition using 16S rRNA sequencing. Results revealed significantly reduced microbial diversity and altered bacterial profiles, notably lower levels of Bifidobacterium and Faecalibacterium and increased Proteobacteria, in advanced AD stages. Correlations were observed between cognitive declines and reduced alpha diversity. Thus, we show gut dysbiosis may play a contributory role in Alzheimer’s pathology.

Source: Bioinformation

DOI: 10.6026/973206300213329

Authors: Prashant Sundeep Gupta, Vedanth Mayakrishna Padmakumar, Omar Imtiaz Usmani

Institutions: Government of Kerala, Era's Lucknow Medical College and Hospital

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414864715