Work

Chagas disease: host responses, parasite evasion and vaccine advances

Year: 2025

Type: article

Abstract: Chagas disease is a parasitic infection caused by Trypanosoma cruzi. Although the host immune response has been extensively studied, important knowledge gaps remain, particularly regarding the complex and multifaceted immune evasion mechanisms employed by the parasite, both at the innate and adaptive levels. In recent years, multiple promising vaccine candidates have been developed, but further evaluation is needed across the different phases of clinical trials. Therefore, the aim of this review is to examine the host immune response to T. cruzi, the parasite's immune evasion strategies and recent advances in vaccine development aimed at controlling infection.

Source: Transactions of the Royal Society of Tropical Medicine and Hygiene

DOI: 10.1093/trstmh/traf109

Author: Héctor Serrano-Coll

Institutions: Instituto Colombiano de Medicina Tropical, Universidad CES

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,067