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Possible Effect of Atorvastatin in Preventing Hemorrhagic Cystitis Induced by Cyclophosphamide in Rats

Year: 2025

Type: article

Abstract: Cyclophosphamide (CP) is an antineoplastic agent used for the treatment of many neoplastic and inflammatory diseases. Hemorrhagic cystitis is a frequent side effect of CP. Several studies show’s that atorvastatin has importantpleiotropic (anti-inflammatory and immunomodulatory) effects. The purpose of the study was to investigate the effect of atorvastatin in prevention from HC induced by CP. Thirty rats were divided into 5 main groups: Control, CP,CP and MESNA, CP and Atorvastatin, CP- MESNA and Atorvastatin. The bladder was collected and histopathological evaluated. Atorvastatin Show’s significant reduction in HC scoring, MESNA still superior than Atorvastatin inprevention of HC, combination both Ator And MESNA show’s no additive effect.

Source: Misurata Medical Sciences Journal

DOI: 10.36602/mmsj/2016.n04.11

Authors: Jamal Dammona, Khaled Makhluf Elzergani, Najlla Alborke, Nada Alreahy

Institution: Misurata University

Language: English

Topic: Chemotherapy-induced organ toxicity mitigation

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4414874826

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