Year: 2025
Type: article
Study design: Case Report
Abstract: Organophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine. A 45-year-old male plumber was admitted to the emergency department 4 h after ingesting an unknown quantity of a 50% emulsifiable concentration of diazinon. He presented with sialorrhea, excessive tearing, emesis, and constricted pupils. Laboratory tests revealed a significant reduction in serum cholinesterase activity. A chest X-ray showed no signs of pulmonary edema or lung abnormalities. The patient was found to be moderately dehydrated and was managed with intravenous normal saline (20 mL/kg) during the first 4 h of treatment. He received 1770 mg of pralidoxime over the first 12 h, along with 9.44 mg of atropine in the first 8 h, followed by 84.96 mg of atropine over the next 3 days. The patient's condition significantly improved after 48 h of intensive treatment, with symptom resolution and normalization of cholinesterase levels. His neurological function progressively returned to normal, and he was discharged on day seven without any lasting complications, having made a full recovery. This case highlights the critical importance of prompt diagnosis and immediate treatment of organophosphate poisoning to prevent life-threatening outcomes. Continuous monitoring and appropriate supportive care are essential for ensuring a successful recovery.
Source: Clinical Case Reports
DOI: 10.1002/ccr3.71183
Author: Gudisa Bereda
Institution: Rift Valley University
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,820
OpenAlex ID: W4414878155