Work

Unmasking Upper Airway Obstruction: A Case of Tracheobronchial Amyloidosis

Year: 2025

Type: article

Abstract: We present a rare case of a 76-year-old woman with severe tracheobronchial amyloidosis (TBA) causing airway collapse, in which the predominant underlying mechanism was expiratory central airway collapse (ECAC) secondary to both TBA and severe obstructive sleep apnoea (OSA). CPAP therapy effectively treated severe OSA, which likely contributed to a reduction in ECAC severity and alleviation of breathlessness. This case suggests that positive airway pressure ventilation may represent a valuable adjunctive treatment in patients with TBA exhibiting features of OSA, particularly when endobronchial intervention is contraindicated or not feasible.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70357

Authors: Abhir Nainani, Chui Lyn Leong, Vishnu Jeganathan, Siven Seevanayagam, Nicole Goh, Celia Lanteri

Institutions: Austin Hospital, Austin Health, Bendigo Health

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,130