Work

Sulfenylcarbenes and sulfenylnitrenes in organic synthesis

Year: 2025

Type: review

Abstract: Sulfenylcarbenes and sulfenylnitrenes are ambiphilic intermediates possessing an unoxidized sulfur atom adjacent to their reactive center. Their unique properties and tunable reactivity make them a model species for studying carbenes and nitrenes in cycloaddition reactions, atom incorporation, late-stage functionalizations, among other applications. They have gained significant attention recently and hold considerable promise for novel reaction development and discovery. Herein, we analyze the chemistry of sulfenylcarbenes and sulfenylnitrenes, emphasizing their generation and applications in contemporary organic synthesis.

Source: Chemical Society Reviews

DOI: 10.1039/d5cs00278h

Authors: Prakash Kafle, Deacon Herndon, Indrajeet Sharma

Institution: University of Oklahoma

Language: English

Topic: Chemical Reactions and Mechanisms

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: University of Oklahoma, American Chemical Society Petroleum Research Fund, Office of the Vice President for Research and Partnerships

Award: G627574165