Year: 2025
Type: conference-abstract
Abstract: 399 Background: Performance status (PS) is central to cancer care, informing prognosis, treatment decisions, and trial eligibility. Clinician-assessed PS (CAPS), typically using ECOG or Karnofsky Performance status (KPS) scales, is often inconsistently or inaccurately documented. Patient-reported PS (PRPS) offers a feasible, patient-centered alternative. This scoping review synthesizes the literature on PRPS’s concordance with CAPS and its prognostic value in cancer care. Methods: We performed a scoping review on PubMed for English-language studies on adult cancer patients until April 8, 2025, comparing PRPS and CAPS, focusing on concordance and survival outcomes. A librarian assisted with optimizing our search criteria, and a predefined protocol was created, detailing inclusion and exclusion criteria for screening at three stages: title, abstract, and full-text review. Reference lists of included studies were manually screened for additional articles. Dual independent review was conducted at all stages. We included observational studies, prospective studies, and trials; non-English, pediatric, and non-oncology studies were excluded. Results: Our initial search revealed 301 titles, and subsequent dual review at each stage resulted in 30 abstracts, 10 full-text articles, identifying 8 eligible studies. An additional 12 were included through citation review, yielding 20 total studies. PRPS tools included patient-assessed KPS, ECOG, and the functional domain of the Patient Generated Subjective Global Assessment (PG-SGA). Among 18 studies evaluating PRPS–CAPS concordance, authors reported a range of fair-to-excellent agreement across the studies. Of the 18 studies that compared PRPS and CAPS, authors of 14 (77.8%) studies reported that patients rated their performance status worse than clinicians. Of the 11 studies that studied survival, 10 (91%) studies found that both PRPS and CAPS predicted overall survival. Conclusions: PRPS and CAPS offer complementary perspectives on functional status. There is some evidence to show concordance between PRPS and CAPS, and that PRPS may have similar prognostic value. This supports further research to understand how integration of PRPS into routine care may better capture patient-centered experiences, and potentially identify patients who may benefit from specialty palliative care referrals or trial eligibility.
Source: JCO Oncology Practice
Authors: Sonal Gandhi, Manan P. Shah, Anne M Walling
Institution: University of California, Los Angeles
Language: English
Topic: Cancer survivorship and care
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4414893566
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