Year: 2025
Type: article
Abstract: This literature review looks at how phytotherapy affects immune regulation in degenerative diseases like neurodegenerative, autoimmune, and metabolic disorders. We begin by outlining a theoretical framework that explains how chronic inflammation, caused by pathways such as NF-κB and the NLRP3 inflammasome, plays a central role in these conditions. Next, we explore how different phytochemicals, including flavonoids, stilbenes, and phenolic acids, achieve their therapeutic effects by influencing these important inflammatory pathways, lowering cytokine production, and offering antioxidant support. The review applies this knowledge to specific diseases, emphasizing how compounds like curcumin and resveratrol may help reduce neuroinflammation and improve immune balance. Finally, we discuss the main challenges related to bioavailability and standardization, suggesting future research paths to realize the full potential of these natural compounds as effective strategies for managing chronic degenerative conditions.
DOI: 10.58511/42dkv065
Authors: Desi Nadya Aulena, Iqbal Julian
Institution: Pancasila University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4414895983
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