Acute Liver Failure Secondary to Herpes Simplex Virus Hepatitis Following Gynecologic Surgery
Year: 2025
Type: article
Study design: Case Report
Abstract: Herpes simplex virus (HSV) hepatitis is a lethal cause of acute liver failure (ALF). This is likely due to its nonspecific clinical presentation delaying diagnosis. There are a handful of case reports describing HSV hepatitis in pregnancy, but there are no published cases associating HSV hepatitis with gynecologic surgery (GS). We report HSV-associated ALF progressing to death in 2 young patients who are immunocompetent without significant medical comorbid conditions. Both patients had GS preceding their liver injury. This highlights a possible predisposition to HSV hepatitis following GS and suggests heightened clinical suspicion and consideration of empirical acyclovir in patients presenting with ALF following GS.
Authors: Michael D. Tiongson, Michelle D'Souza, Mark Ettel, Priya D. Farooq
Institutions: University of Rochester Medicine, University of Rochester
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414902444