Year: 2025
Type: article
Study design: Case Report
Abstract: Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia, historically linked to syphilis and mainly seen in children. We report a case in a young adult during fall, following a recent upper respiratory infection. Common infectious triggers were ruled out and imaging showed no masses. The patient presented with severe anemia (hemoglobin level, 3.6 g/dL) and received steroids, 2 rituximab infusions, and 9 units of packed red blood cells. His symptoms improved and he was discharged after 12 days on oral steroids with stable hemoglobin. This case highlights the importance of recognizing atypical adult presentations of PCH.
Authors: Mohammed Abdelfattah, Ahmed Ali, Doris Akolbire, Abay Gobezie, Amoafo D. Boampong, Nicholas Azinge
Institution: Howard University Hospital
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414902445