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Mixed Cold and Warm Autoimmune Hemolytic Anemia Following Babesiosis in an Immunocompromised Patient

Year: 2025

Type: article

Abstract: Babesiosis is a tick-borne infection diagnosed by characteristic intracellular inclusions on peripheral blood smears. While nonimmune hemolytic anemia is a known complication of babesiosis infection, autoimmune hemolytic anemia caused by babesiosis infection is much more rare. Here, we describe a case of cold agglutinin syndrome in a patient with babesiosis infection who was also on ofatumumab therapy for multiple sclerosis. The patient continued to have evidence of hemolysis after appropriate antimicrobial therapy and after clearance of peripheral blood smears. This case illustrates a need for further research into CAS associated with babesiosis infection.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2025.0405

Authors: Brooke Escoe, Philip Mardock, Diane Olski, Robert Sherertz, Mohamed Faris

Language: English

Topic: Vector-borne infectious diseases

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: HCA Healthcare

OpenAlex ID: W4414902446

FWCI:

Cites: 11

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