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Methemoglobinemia-Induced Cardiac Dysfunction in a Pediatric Patient

Year: 2025

Type: article

Abstract: Methemoglobinemia is a rare congenital or acquired cause of functional anemia resulting from oxidation of hemoglobin. Prompt recognition and treatment are critical to prevent tissue hypoxia and end-organ injury. While other complications are well described, cardiac dysfunction is rarely reported—especially in children. We present what, to our knowledge, is the first known case of methemoglobinemia-induced transient cardiac dysfunction—or “myocardial stunning—in a pediatric patient. This case underscores the importance of maintaining a high index of suspicion and assessing cardiac involvement in such patients. Early intervention can lead to full recovery and prevent long-term sequelae, even in the presence of multiorgan failure.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2025.0671

Authors: Brian Drury, Chelsea Boyd, Kelsey Van Housen, Siraj Amanullah

Institutions: Oregon Health & Science University, Baylor College of Medicine, Thomas Jefferson University, Brown University

Language: English

Topic: Methemoglobinemia and Tumor Lysis Syndrome

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414902469

FWCI:

Cites: 7

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