Work

Sex cord-like elements in Müllerian lesions: Report of two rare cases and review of the literature

Year: 2025

Type: article

Abstract: Sex cord-like elements (SCLEs) are uncommon in non-ovarian sex cord lesions in the female genital tract and are most commonly observed in uterine endometrial stromal tumors (EST) and uterine tumors resembling ovarian sex cord tumors (UTROSCT). Here, we describe two rare cases harboring SCLEs. The first case was a 72-year-old female with postmenopausal bleeding. Endometrial curettage showed endometrial polyps with SCLEs, confirmed by immunohistochemical staining for calretinin, Melan A, and inhibin. The second case was a 71-year-old female with a complex cystic and solid mass in the left ovary, and bilateral salpingo-oophorectomy revealed an ovarian adenosarcoma with extensive SCLEs. Both patients recovered well and the presence of SCLEs did not change the fate of the parent lesions. Our report highlights the importance of awareness of SCLEs in these Müllerian lesions, although exceedingly rare, to avoid diagnostic confusion.

Source: Human Pathology Reports

DOI: 10.1016/j.hpr.2025.300799

Authors: Bahadir Yildiz, Huina Zhang, Jamie Linn McDowell, Hani Katerji, Sharlin Varghese, Xi Wang

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Uterine Myomas and Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160