Year: 2025
Type: article
Study design: Case Report
Abstract: The leukemic phase of diffuse large B-cell lymphoma (DLBCL) is a rare condition and can be difficult to distinguish from acute leukemia or the leukemic phases of other non-Hodgkin lymphoma subtypes.When intermediate-to-large abnormal lymphoid cells are observed in the peripheral blood, it should be considered as one of the differential diagnoses.Flow cytometry and immunohistochemical staining are helpful for definitive diagnosis.The leukemic phase typically occurs in the progressive phase or stage IV disease and is rare at the time of initial diagnosis in DLBCL.The development of a leukemic phase during the course of the disease is particularly associated with poor prognosis.There are no evidence-based treatment recommendations for this condition.In our case, we presented a patient with DLBCL who developed a leukemic phase upon second relapse.
Source: Namık Kemal Tıp Dergisi
Authors: Sinan DEMİRCİOĞLU, İbrahim GÜRBÜZ, Naile KÖKBUDAK, Hacı Hasan ESEN, Atakan TEKİNALP
Institution: Necmettin Erbakan University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414912642
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