Supplementary Figures S1-S13 from Mutagenic Impact and Evolutionary Influence of Chemoradiotherapy in Hematologic Malignancies
Year: 2025
Type: supplementary-materials
Abstract: Figure S1: Overview of the Single-Cell Expansion Model. Figure S2: Mutational Profiles of Chemoradiotherapy-Treated Lymphoid Patients. Figure S3: ID83 signature relationships to SBS96 signatures in newly diagnosed MM and BCL. Figure S4: ID8-associated Peaks in ID8-negative Cases. Figure S5: Indel profiles of select ID8-positive subgroups. Figure S6: Similarity of ID8 Regardless of Disease Histology. Figure S7: Genomic Complexity has No Bearing on ID8 Contribution. Figure S8: De novo SBS96 and ID83 extractions for single-cell derived colonies. Figure S9: De-noised SBS96 profiles. Figure S10: De-noised ID83 Profiles. Figure S11: ID8 Fitting to a Melphalan-exposed Cell Line. Figure S12: Median profiles of sublethal-dose platinum and RT single-cell-derived colonies showing global contribution of ID8 in both exposure types. Figure S13: ID8 presence in t-MN.
Authors: Benjamin Diamond, Dhanvantri Chahar, Michael D. Jain, Alexandra M. Poos, Michael A. Durante, Bachisio Ziccheddu, Marcella Kaddoura, Marios Papadimitriou, Kylee H. Maclachlan, Tomas Jelinek, Faith E. Davies, Nicholas B. Figura, Gareth J. Morgan, Elias K. Mai, Katja Weisel, Roland Fenk, Marc S. Raab, Saad Usmani, Ola Landgren, Frederick L. Locke, Hartmut Goldschmidt, Jonathan Harry Schatz, Niels Weinhold, Francesco Maura
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4414912943
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