Work

Trigonelline activates NRF2 and awakens dormant ovarian follicles to promote pregnancy in aging mice

Year: 2025

Type: article

Abstract: . Elevated epidermal growth factor (EGF) levels activate EGF receptor (EGFR), increasing protein kinase B (AKT) phosphorylation, which leads to FOXO3A nuclear extrusion and primordial follicle activation. These findings demonstrate that transient NRF2 activation is sufficient to initiate primordial follicle activation and follicle growth and development.

Source: iScience

DOI: 10.1016/j.isci.2025.113717

Authors: Mahboobeh Amoushahi, Emil Hagen Ernst, Anders Heuck, Margit Dueholm, Erik Ernst, Karin Lykke-Hartmann

Institutions: Aarhus University, Regional Hospital Horsens, Aarhus University Hospital

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240