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Do Aminopenicillins Have a Role in Treating Ampicillin-Resistant Enterococcus UTIs?

Year: 2025

Type: article

Abstract: Urinary tract infections caused by Enterococcus species are a frequent clinical challenge. The rising prevalence of ampicillin resistance often seemingly precludes the use of aminopenicillins. However, evidence suggests that aminopenicillins may retain clinical efficacy, even when susceptibility testing indicates resistance. Integrating available pharmacokinetics/pharmacodynamics and clinical data and risk-benefit considerations, we seek to address the question: Can aminopenicillins still be a viable treatment option in the management of ampicillin-resistant Enterococcus infections?

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofaf619

Authors: Armani M Hawes, Pranita D Tamma, Navaneeth Narayanan

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Rutgers, The State University of New Jersey

Language: English

Topic: Urinary Tract Infections Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053