Work

Pulmonary tumour thrombotic microangiopathy: case report of a rare cause of right ventricular acute pressure overload

Year: 2025

Type: article

Abstract: Background: Pulmonary tumour thrombotic microangiopathy is a rare complication observed in patients with cancer, causing mainly progressive but sometimes acute pulmonary hypertension. Case summary: A patient with a recent transcatheter aortic valve implantation and a localized urothelial carcinoma on the urinary bladder presented with acute pressure overload of the right ventricle which led to refractory shock resulting in death. The initial suspicion was pulmonary thromboembolism, but he was finally diagnosed with tumour thrombotic microangiopathy at autopsy. Discussion: Pulmonary tumour thrombotic microangiopathy can lead to an abrupt clinical picture of respiratory failure and shock, similar to pulmonary thromboembolism, but with a completely different aetiology. Unfortunately, the diagnosis is usually made at autopsies. This case illustrates a rare but important cause in the differential diagnosis of acute pressure overload in the right ventricle, especially in patients with known malignancy.

Source: European Heart Journal - Case Reports

DOI: 10.1093/ehjcr/ytaf514

Authors: Víctor García-Hernando, Jordi Sans Roselló, Pablo Carrion Montaner, Carmen Maria Blazquez Maña, Antoni Martínez Rubio

Institution: Corporació Sanitària Parc Taulí

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $815