Work

Beyond Hormone Replacement: Multifaceted Effects of Phytoestrogens for Optimizing Kinesiological and Physiological Adaptations in Postmenopausal Women

Year: 2025

Type: article

Abstract: Phytoestrogens (PEs), a class of naturally occurring plant compounds primarily categorized into isoflavones, lignans, flavonoids, coumarins, and stilbenes, exhibit structural similarity to endogenous estrogens and exert regulatory effects through estrogen receptors. This comprehensive review examines the multifaceted roles of PEs in enhancing exercise performance and promoting health among postmenopausal women. Current evidence demonstrates that PEs not only ameliorate characteristic menopausal symptoms but, more significantly, improve physical function through multiple mechanisms: (1) augmenting muscle protein synthesis while mitigating inflammation and oxidative stress to optimize muscular performance; (2) modulating glucolipid metabolism and cardiovascular function to establish physiological foundations for exercise; and (3) preserving bone mineral density and regulating neurotransmitter activity to maintain motor coordination. Although combined PE-exercise interventions demonstrate synergistic benefits, their efficacy is influenced by dosage variations and interindividual metabolic differences. Future investigations should prioritize the development of precision PE applications to optimize kinesiological outcomes and health parameters in postmenopausal populations.

Source: Clinical Interventions in Aging

DOI: 10.2147/cia.s539923

Authors: Yingjia Hu, Yi Hu, Tao Li, Rengfei Shi

Institution: Shanghai University of Sport

Language: English

Topic: Phytoestrogen effects and research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836