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Antihyperglycemic and antioxidant potential of Curcuma caesia in mitigating oxidative stress and tissue damage in mice with STZ-induced diabetes

Year: 2025

Type: article

Abstract: Aim: (MECC) in mitigating oxidative stress and tissue damage in mice with streptozotocin (STZ)-induced diabetes. Objective: The objective aims to examine the effects of MECC on fasting blood glucose (FBG), glucose tolerance, antioxidant enzyme activity, lipid peroxidation, and histopathological alterations in the liver and kidneys of diabetic mice. Method: Male Swiss albino mice were categorized into normal untreated control, diabetic untreated control, and diabetic + ascorbic acid-treated, diabetic + MECC treated (350 mg/kg body weight [b.w.]). Diabetes was induced using STZ, and the effects of MECC were assessed through FBG, intraperitoneal glucose tolerance tests, and measurement of oxidative stress markers such as thiobarbituric acid reactive Substances (TBARS), superoxide dismutase (SOD), and catalase (CAT). Histopathological analysis of kidney and liver tissues was performed to evaluate tissue damage and recovery. Results: MECC treatment at 350 mg/kg b.w. significantly decreased the FBG levels in diabetic control mice, with effects comparable to standard antihyperglycemic drugs like metformin and glibenclamide. Glucose tolerance was notably improved, and oxidative stress markers, including TBARS, were normalized in treated groups. Antioxidant enzyme activity (SOD and CAT) was restored in the liver and kidneys. Histopathological analysis revealed substantial recovery of tissue architecture, with nearly normal glomeruli and hepatocytes in diabetic-MECC-treated mice, indicating protection against diabetes-induced damage. Conclusion: MECC demonstrated potent antihyperglycemic, antioxidant, and tissue-protective effects in diabetic mice, suggesting its capability as a treatment option for diabetes management. Further evaluation is needed to investigate its potential clinical uses.

Source: Annals of Medicine and Surgery

DOI: 10.1097/ms9.0000000000003755