Segmental airway adenocarcinoma-simulating phantom for endoscopic near-infrared optical coherence tomography
Year: 2025
Type: article
Abstract: SignificanceThere is an unmet need for readily accessible imaging targets to verify whether devices can discriminate lesions from healthy tissue and identify sub-surface vasculature in the small airways.AimOur aim is to develop a phantom that mimics human segmental airway adenocarcinoma in vivo for 1310 nm endoscopic optical coherence tomography (OCT) and angiography characterization.ApproachWe develop phantoms using a mixture of agar, intralipid, and coconut oil cured in a 3D printed mold with embedded tubing to mimic vasculature. The parenchyma optical attenuation coefficient (OAC) is calibrated using optical transmission measurements from an agar and intralipid dilution series. Depth-resolved OAC histogram distributions, analysis of variance, and image quality are used to assess repeatability and biofidelity of these phantoms.ResultsTransmission measurements show large increases in OAC when intralipid is cured with agar compared with water-intralipid dilutions. Representative phantom OACs show repeatability within 2.7% and match normal in vivo tissue measurements within 16%. Embedded lesion phantoms achieve imaging characteristics of in vivo adenocarcinoma. Fluid flow within embedded tubing is visualized with Doppler OCT.ConclusionsThe segmental airway phantoms demonstrate in vivo human imaging characteristics, including structural and optical markers of pathological progression—providing a platform for imaging system characterization and optimization.
Source: Journal of Biomedical Optics
Institutions: University of British Columbia, Simon Fraser University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,675
OpenAlex ID: W4414930474
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