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Switchable pathways of multicomponent heterocyclizations of 5-amino-1,2,4-triazoles with salicylaldehydes and pyruvic acid

Year: 2025

Type: article

Abstract: Switchable multicomponent reactions involving 3-substituted-5-amino-1,2,4-triazoles, pyruvic acid, and salicylaldehydes were studied under different conditions. Upon conventional heating, benzotriazolooxadiazocine-5-carboxylic acids were formed in the three-component reactions as single reaction products. Upon ultrasonic activation or mechanical stirring at room temperature, the multicomponent reaction of the same starting materials led to the formation of only tetrahydrotriazolopyrimidine derivatives.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.21.158

Authors: Yana I Sakhno, Oleksander V Buravov, Kostyantyn Yu Yurkov, Anastasia Yu Andryushchenko, Svitlana V Shishkina, Valentyn A Chebanov

Institutions: State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Enamine (Ukraine), V. N. Karazin Kharkiv National University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Research Foundation of Ukraine, National Research Foundation, National Academy of Sciences of Ukraine

OpenAlex ID: W4414930878