Work

Association of Area Deprivation with Chronic Kidney Disease in Pediatric Sickle Cell Anemia

Year: 2025

Type: preprint

Abstract: Social determinants of health have been associated with increased morbidity and mortality, including for chronic kidney disease (CKD). We performed a retrospective cohort study in 318 pediatric patients living with sickle cell anemia (SCA) to assess the association of persistent albuminuria with neighborhood-level deprivation and food access. Additionally, we mirrored this study to determine the effect of food insecurity on CKD in the SCA murine model. Fifty six cohort participants (17.6%) had persistent albuminuria. Participants living in deprived neighborhoods had 1.89 greater odds of having persistent albuminuria (p=0.035). We did not identify a significant difference for patients living in food deserts (p=0.44) or murine SCA model. Interventions that address social disparities in our sickle cell population may improve clinical outcomes.

DOI: 10.22541/au.175992132.23169840/v1

Authors: Alexandria Broadnax, Mohammad O. Sako, Gabriela R. Oates, Elizabeth H. Baker, Bryant Kane, Malgorzata Kasztan, Jeffrey Lebensburger

Institutions: University of Alabama at Birmingham, UAB Medicine, University of North Carolina at Chapel Hill

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: gold

OpenAlex ID: W4414933749

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