Mitochondria‐Targeted Delivery of siRNA by Amphiphilic Nanovectors Self‐Assembled from a Cationic [4]Helicene‐Squalene Ester
Year: 2025
Type: article
Abstract: The active delivery of therapeutic nucleic acids with subcellular precision is an open challenge. Herein, a small conjugate molecule, combining a cationic [4]helicene moiety with a lipophilic squalene tail, yields amphiphilic nanoassemblies capable of effectively complexing siRNA within the mitochondria. A proof-of-concept in HCT 116 colorectal cancer cells was evidenced by Western blot for the delivery of siRNA silencing the protein expression of the mitochondria-encoded cytochrome c oxidase subunit 1 gene.
Source: ChemBioChem
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,430
Funders: National Science Foundation, Biogen, Association pour la Recherche sur le Cancer, Agence Nationale de la Recherche, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Fondation ARC pour la Recherche sur le Cancer, Centre National de la Recherche Scientifique, Université de Genève
Awards: Superstable Cations and Reactive ylides for Synthesis, Catalysis and (Bio)Optical Applications, G2982085409, G4846016329, G628552264, Superstable Chiral Cations and Reactive Ylides for Synthesis, Catalysis and Optical Applications, France-BioImaging (Biological Imaging Next-Generation Instrument)
OpenAlex ID: W4414934279