Decreased albumin to INR ratio is a prognostic marker of 30-day mortality in neonatal sepsis: a retrospective study
Year: 2025
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Neonatal sepsis is a leading cause of neonatal mortality. This study aims to assess the clinical significance of the serum albumin (ALB) to international normalized ratio (INR) ratio (AIR) as a predictor for 30-day mortality in neonates with sepsis. METHODOLOGY: Neonates diagnosed with sepsis between January 2019 and December 2022 were included. Admission data were collected, enabling the categorization of neonates into survival and non-survival groups. Logistic regression analyses and receiver operating characteristic (ROC) curves, were employed. RESULTS: A total of 195 neonates with sepsis were analyzed. The non-survival group exhibited significantly lower AIR compared to the survival group. Multivariate analysis identified low AIR as an independent risk factor (hazard ratio [HR]: 9.091, p < 0.001), achieving an area under the curve (AUC) of 0.746 for AIR. The sensitivity and specificity of AIR were 79.31% and 66.87%, respectively. CONCLUSIONS: AIR serves as a cost-effective and easily obtainable marker in neonatal sepsis research. It emerges as an independent predictor of adverse outcomes in neonatal sepsis, demonstrating good predictive capabilities.
DOI: 10.3855/jidc.20968
Authors: Xiangwen Tu, Junkun Chen, Wen Liu
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $394
OpenAlex ID: W4414938256