Work

NADPH oxidase 1-PKCδ-dependent ZO-1 phosphorylation mediates IL-33-induced inner blood-retinal barrier disruption in proliferative retinopathies

Year: 2025

Type: article

Abstract: The significance of blood-retinal barrier integrity in proliferative retinopathies, including retinopathy of prematurity and diabetic retinopathy, is still in its nascent phase. Using human retinal microvascular endothelial cells and an oxygen-induced retinopathy animal model, we demonstrate that IL-33-mediated NOX1-PKCδ-ZO-1 signaling regulates tight junction disruption and blood-retinal barrier integrity in ischemic retinal diseases.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00308.2025

Authors: Geetika Kaur, Shivantika Bisen, Anamika Sharma, Nikhlesh K. Singh

Institution: Wayne State University

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Research to Prevent Blindness, National Eye Institute