Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents
Year: 2025
Type: article
Abstract: This study uses intersectional chemogenetics, radiotelemetry, and whole body plethysmography to determine the effect of selective stimulation of distinct sensory nerve subsets on cardiorespiratory function in awake mice. We show that TRPA1 + afferents evoke greater reflex bradycardia than TRPV1 + afferents. We show that P2X2 + (nodose) afferents induce bradypnea through an increased time of pause, whereas Tac1 + TRPV1 + (jugular nociceptive) afferents induce bradypnea through prolongation of expiration. Thus, distinct afferent subsets can differentially regulate cardiorespiratory function.
Source: Journal of Neurophysiology
Institution: University of South Florida
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4414939606