Year: 2025
Type: article
Study design: Case Report
Abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare and potentially life-threatening condition characterized by fever, microangiopathic hemolytic anemia, thrombocytopenia, renal injury, and neurologic dysfunction. Until the advancements in treatment modalities in the late 20th century, TTP had carried a very high mortality risk. Treatment based on established guidelines has drastically reduced mortality rates, making early diagnosis and therapeutic intervention critically important. This case report discusses two patients diagnosed with TTP who had varying presentations, treatment courses, and recovery. The first case involves a 19-year-old male who initially presented with symptoms of a headache with some migraine-like features, which progressed to more severe neurological deficits before the diagnosis was made. The second case describes a 61-year-old female who presented with slurred speech but was seen to have TTP, which was refractory to initial management.
Source: Cureus
DOI: 10.7759/cureus.94145
Authors: Pragnesh D Patel, Devon Thorpe, Anita Sultan
Institution: Overlook Medical Center
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414943554