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Severe Necrotizing Pneumonia Caused by Panton‑Valentine Leukocidin‑Producing Staphylococcus aureus in a Previously Healthy Adult

Year: 2025

Type: article

Abstract: A previously healthy adult male presented with rapidly progressive pneumonia and systemic features of infection shortly after returning from travel abroad. Despite broad‑spectrum antimicrobial therapy and supportive measures, he deteriorated into respiratory failure requiring ICU admission and mechanical ventilation. Imaging revealed cavitating lung nodules and necrosis. Panton-Valentine leukocidin (PVL)‑positive Staphylococcus aureus (PVL‑SA) was confirmed by PCR. This case highlights the importance of early recognition and targeted management of PVL‑SA, a virulent toxin‑producing strain associated with severe necrotizing pneumonia and systemic complications, especially in young, otherwise healthy individuals.

Source: Cureus

DOI: 10.7759/cureus.94097

Authors: Prabin Paudyal, Pallavi Bedi

Institution: NHS Lanarkshire

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414947396