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What About Autologous Stem-Cell Transplantation in Primary Central Nervous System Lymphoma?

Year: 2025

Type: article

Abstract: Autologous hematopoietic stem-cell transplantation (ASCT) as consolidation after high-dose methotrexate (HD-MTX)-based induction chemotherapy has emerged as an effective strategy for achieving durable remissions while reducing the need for whole-brain radiotherapy (WBRT) and its associated neurotoxicity risks, according to meta-analyses, randomized trials, and systematic reviews [1,2,13,3]. In younger, eligible patients, randomized studies report comparable efficacy between WBRT and high-dose chemotherapy followed by ASCT, but with superior neurocognitive tolerance after ASCT supporting its preferential use as consolidation in selected patients [2,13].

Source: Scholars Journal of Medical Case Reports

DOI: 10.36347/sjmcr.2025.v13i10.004

Authors: W.S. Ouedraogo, M.A. Aznag, M. Hamidine, K.O. Josias, S. Achouch, A. Raissi

Institution: Hôpital Militaire Avicenne

Language: English

Topic: CNS Lymphoma Diagnosis and Treatment

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414948278

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