Work

Xenotransplantation: Promises and Perils

Year: 2025

Type: review

Abstract: Xenotransplantation of genetically modified pig organs has the potential to change the landscape of transplantation and chronic disease management by providing limitless personalized organs on demand. Decades of progress have resulted in recent US Food and Drug Administration approval for human clinical trials. Understandably, hope for the field is at a maximum, fueled by exciting anecdotal experiences, each providing new insights and questions. While further work is needed before widespread clinical application is plausible, the promise of xenotransplantation has never been more evident. In this review, we seek to highlight recent progress, suggest remaining research questions, and touch on the future of the field.

Source: Annual Review of Medicine

DOI: 10.1146/annurev-med-043024-015252

Authors: Joseph M. Ladowski, Nagham Bazzi, Allan D. Kirk

Institutions: Duke University, Duke Medical Center

Language: English

Topic: Xenotransplantation and immune response

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Allergy and Infectious Diseases