Work

Phytochemical profile and in vitro bioactivities of ethanolic extract from Fructus Ligustri Lucidi

Year: 2025

Type: article

Abstract: This study aims to characterize compounds in Fructus Ligustri Lucidi ethanolic extract (FLLEEs) and evaluate their in vitro biological activities. A total of 71 compounds were identified using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry, primarily phenols, triterpenes, and iridoids. Among these, 53 were phenolics, including iridoids, flavonoids, flavonols, flavanols, phenolic acids, phenylethanoid glycosides, and coumarins. Notably, 51 compounds were first reported in FLLEEs. The antioxidant capacity of FLLEEs was assessed using seven complementary assays, including DPPH, ABTS, and so on. FLLEEs showed strong activity, with EC50 of 42.04 ± 1.41 μg/mL (DPPH) and 11.06 ± 0.29 μg/mL (ABTS). Furthermore, FLLEEs demonstrated notable multi-enzyme inhibitory effects. Especially, the α-amylase inhibitory activity (IC50 = 2.08 ± 0.14 mg/mL) surpassed that of acarbose (IC50 = 2.76 ± 0.11 mg/mL), indicating potential for blood glucose management. This study provides a scientific basis for developing natural antioxidants and blood-glucose management functional products.

Source: CyTA - Journal of Food

DOI: 10.1080/19476337.2025.2570048

Authors: Heng Yuan, Yanfeng Zhu, Yu He, Jing Ren, Chao Li

Institution: Xuzhou University of Technology

Language: English

Topic: Phytochemistry and Biological Activities

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,790