Work

Co 3 O 4 -Promoted Cerium Oxide Catalyst for Efficient Catalytic N -Alkylation of Amines with Alcohols

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The use of heterogeneous catalysts to generate amine compounds through anaerobic N -alkylation of alcohols via hydrogen transfer strategy is a highly promising synthetic strategy, as it can construct C–N bonds under relatively mild and green conditions. Moreover, amine compounds are widely used in the synthesis of pharmaceutical intermediates, agriculture and fine chemicals. In this work, we successfully constructed a novel Co 3 O 4 /CeO 2 catalyst using the hydrothermal synthesis method and applied it to the N -alkylation reaction of alcohols, achieving up to 99% of the target product yield with broad substrate scope and high catalyst stability. The Ce 3+ /Ce 4+ redox pairs and oxygen vacancies in the CeO 2 support with highly dispersed Co species synergistically catalyze the hydrogen borrowing process of alcohols and amines to generate secondary amines with high activity and selectivity.

Source: ACS Organic & Inorganic Au

DOI: 10.1021/acsorginorgau.5c00069