Short- to Mid-term Safety and Efficacy of Prostatic Artery Embolization Using N-Butyl Cyanoacrylate for Symptomatic Benign Prostatic Hyperplasia – A Single-center Experience
Year: 2025
Type: article
Study design: Observational Study
Abstract: Aims: To assess the safety and efficacy of prostatic artery embolization (PAE) using n-butyl cyanoacrylate (n-BCA) for symptomatic benign prostatic hyperplasia (BPH). Settings and Design: It is retrospective analysis of 17 consecutive patients with symptomatic BPH who underwent PAE using n-BCA at the Department of Peripheral Vascular and Endovascular Sciences, Medanta – The Medicity, Gurugram, Haryana, between January 2020 and December 2023. Subjects and Methods: The primary outcome assessed was improvement in the International Prostate Symptoms Score (IPSS) from baseline to 12 months. The secondary outcomes assessed were improvements in IPSS-associated quality-of-life score (IPSS-QoL), maximum flow rate on uroflowmetry (Qmax), prostate gland volume (PGV), residual void volume (RVV), and serum prostate-specific antigen (PSA). Adverse events that occurred at any time during the 12-month follow-up were reported according to the Clavien−Dindo grading system. Results: A total of 17 patients underwent PAE with n-BCA with 100% technical success. There were statistically significant improvements from baseline to 12 months for the IPSS (from 18.41 to 6.35, P < 0.001), IPSS-QoL (from 4.94 to 1.76, P < 0.001), Qmax (from 6.05 to 14.97, P < 0.001), RVV (from 179.7 to 44.7, P < 0.001), PSA level (from 4.06 to 2.06, P < 0.001), and PGV (from 72.2 to 30.5, P < 0.001). There were no major adverse events. Conclusions: The findings support the safety of PAE using n-BCA, with excellent technical and mid-term clinical outcomes. Randomized trials with longer follow-ups are needed to solidify n-BCA’s role in the evolving landscape of PAE.
Institutions: Medanta The Medicity, Medanta The Medicity
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414964702