The Comparison of Clinical Aspects of Topical Clotrimazole 1% Cream and Natamycin 5% Ear Drops in the Treatment of Otomycosis
Year: 2025
Type: article
Abstract: Background: Otomycosis is a superficial fungal infection of the ear canal which requires prolonged treatment for patients and clinicians. Objectives: The aim of this study was to compare the clinical aspects of Clotrimazole 1% cream with Natamycin 5% drops in the treatment of otomycosis. Methods: This research used an unpaired numerical comparative analytic study with a parallel trial design. The study sample consisted of 30 patients with otomycosis, divided into two therapy groups; Clotrimazole cream and Natamycin drops. Clinical symptoms (pain, itching and ear fullness) and clinical signs (ear canal condition, secretions and hyphae/spores) were evaluated on days 7 and 14. Subjects were given follow-up therapy in the form of reapplication. Statistical tests were used, including the Mann-Whitney test and Fisher's Exact test. Results: No significant differences were observed in the median of otalgia, itching, and blockage score before and after treatment for Clotrimazole and Natamycin (p=0.825), (p=0.006), (p=0.016), respectively. In addition, there was a significant reduction in the number of patients reporting ear discharge (p = 0.256), secretions (p = 1.0), and hyphae/spores (p = 1.0). Conclusion: There was no significant difference in the clinical outcomes between Clotrimazole cream and Natamycin drops in patients with otomycosis.
Authors: Suci Rahmi, Azwar Ridwan, Dina Alia, Novina Rahmawati, Elvia Haroen
Institution: Universitas Syiah Kuala
Language: English
Topic: Ear Surgery and Otitis Media
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414971745
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