Work

Case Report: Talaromyces marneffei infections associated with pharyngeal and laryngeal injuries in three children with aberrant innate immunity: a case series

Year: 2025

Type: article

Abstract: Background Talaromyces marneffei (T. marneffei) is a pathogenic yeast that causes high fatality rates among immunocompromised individuals. The organism appears to target the lungs, liver, gut-associated lymphoid tissues, lymph nodes, spleen, bone marrow, kidneys, and the tonsils in the affected individuals. Evidence suggests that the lungs and liver are seriously injured in T. marneffei infections. Injuries to the pharyngeal and laryngeal compartments have seldom been reported. Case presentation Three pediatric patients with T. marneffei infections were admitted to the Guangzhou Women and Children's Center between August 2015 and March 2023. All three children showed evidence of pharyngeal and laryngeal injuries. Conclusions Damage to the pharyngeal and laryngeal compartments appears to be an important clinical manifestation among HIV-negative pediatric individuals with a T. marneffei infection.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1615943

Authors: Changhao Zhang, Gen Lu, Xuehua Xu, Huifeng Fan

Institutions: Guangzhou Women and Children Medical Center, Guangzhou Medical University

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801