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Nodular Sclerosis Hodgkin Lymphoma Presenting as Widespread Necrotic Lymphadenopathy: A Case Emphasizing Diagnostic Pitfalls

Year: 2025

Type: article

Abstract: Hodgkin lymphoma (HL) most commonly presents with painless, rubbery lymphadenopathy, whereas necrotic nodes are rare and frequently misattributed to infectious or metastatic etiologies. We report the case of a 44‑year‑old man with widespread necrotic lymphadenopathy involving cervical, abdominal, pelvic, and inguinal regions. Histopathology confirmed nodular sclerosis HL (NSHL) with CD30+/CD15+ Reed–Sternberg cells. The patient achieved complete remission following six cycles of ABVD chemotherapy. This case underscores the diagnostic pitfalls of necrotic lymphadenopathy, particularly in tuberculosis‑endemic regions, and highlights the importance of early excisional biopsy and immunohistochemistry for accurate diagnosis and timely treatment.

Source: SAS Journal of Surgery

DOI: 10.36347/sasjs.2025.v11i10.007

Authors: A. Oussalem, ZA. Baba El Hassene, B. Dani,, M. Boulaadas

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414972530

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