Year: 2025
Type: article
Abstract: Staphylococcus aureus (S. aureus) is a formidable pathogen in humans that can lead to a diverse range of infections, from mild skin issues to serious systemic illnesses.Its frequent appearances and endurance are often linked to its ability to resist both the host's immune responses and antibiotic treatment.Recent research sheds light on a new and previously unexplored aspect of its pathogenesis-its ability to affect the host's epigenetic mechanisms.This examination investigates how S. aureus can modify host chromatin structure through changes in DNA methylation, alterations in histone proteins, and influences on non-coding RNAs, ultimately resulting in the reprogramming of immune responses and cellular processes that support bacterial survival and longevity.This article elaborates on the ways S. aureus affects host cell functions, pointing out potential pathways for enhancing infection biology, diagnostics, and targeted treatments.Consequently, this article encourages further exploration of the epigenetic interactions between host and pathogen as a vital area in combating bacterial persistence.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4414973338
FWCI:
Cites:
Cited by:
Related to: