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Medical source control with oritavancin in complicated gram-positive bacterial infections: A case series

Year: 2025

Type: article

Abstract: OBJECTIVES: This retrospective observational case series describes a population with complicated gram-positive infections treated with oritavancin as part of a highly individualized strategy. DESIGN/METHODS: We conducted a retrospective observational case series of 10 patients with complicated gram-positive infections treated with oritavancin at a tertiary care center. RESULTS: Most patients had multiple comorbidities and previous antibiotic toxicities. Oritavancin was well tolerated, with no reported adverse events. All patients achieved clinical cure, and no relapses were observed during a follow-up of up to 24 months. CONCLUSIONS: These findings suggest it may serve as an effective medical alternative to source control in frail, difficult-to-treat populations.

Source: International Journal of Infectious Diseases

DOI: 10.1016/j.ijid.2025.108111