Work

Response to Comment on “Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis”

Year: 2025

Type: article

Abstract: We greatly appreciate Dr. Szaryńska’s interest in our work, and appreciate her comment on our article published in Advanced Materials in 2018. In a previous publication, Dr. Szaryńska’s group reported that lipopolysaccharide (LPS) increased maturation and activation status of dendritic cells (DCs) in vitro, and hypothesized that LPS may be considered a profitable supplement before launching a DC-based immunotherapy. However, the results from our publication showed that blockade of toll-like receptor 4 (TLR4) pathway or trapping of LPS by gene delivery using lipid–protamine–DNA (LPD) nanoparticles alleviated immunosuppressive microenvironment in an orthotopic colorectal cancer (CRC) mouse model, and promoted immune checkpoint therapy in CRC. Therefore, Dr. Szaryńska commented suggesting the experimental conditions and chosen aspects should be considered in clinical applications of LPS-associated protocols.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/rbqg-ga38

Authors: Liu, Rihe, Huang, Leaf, Song, Wantong

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Natural Science Foundation of China