Microenvironment-responsive size-adaptive nanoparticles: hyaluronidase/acid/NIR light activation for deep-penetration trimodal therapy
Year: 2025
Type: article
Abstract: ABSTRACT The dense tumor microenvironment (TME) hinders drug delivery. Herein, we report hyaluronidase/acid/NIR-responsive, size-adaptive nanoparticles (IDHNs) co-loaded with doxorubicin (DOX) and IR780. IDHNs integrate dual targeting with fissile size: biocompatible HSA prolongs circulation, while HA enables CD44-mediated accumulation and hyaluronidase (HAase)-triggered fission reduces particle size, facilitating deep stromal penetration. Acidic TME and NIR laser irradiation further accelerates drug release, achieving potent chemo-photothermal/photodynamic synergy. In vitro and in vivo studies confirm that IDHNs surpass monotherapies in precision, efficacy, and safety. This trimodal nanoplatform provides a versatile strategy to overcome physical TME barriers and advance tumor-targeted therapy.
Source: Materials Today Bio
Authors: Hao Wu, Hongping Li, Li Li, Yungchang Chen, Hongping Yang, Chongxiu Shi, Wenhao Li, Li Ye, Liming Zhu, Gang He, Suling Luo, Jing Tao, Ling Mei, Xue Shen
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,400
Awards: G1803755025, G8008539083, G8500054538
OpenAlex ID: W4414979082