Work

Relationship between minimum heart rate and mortality in ICU patients with traumatic brain injury (TBI): a retrospective analysis based on the MIMIC-IV database

Year: 2025

Type: article

Abstract: The association between minimum heart rate (MinHR) within 24 hours of ICU admission and 1-month mortality in traumatic brain injury (TBI) patients remains unclear. This retrospective cohort study analyzed 2267 TBI patients from the MIMIC-IV v3.1 database. Multivariable Cox regression, restricted cubic spline (RCS) analysis, and subgroup analyses evaluated relationships between 24-hour MinHR and mortality. The cohort (median age 67 [IQR 51-80] years; 62.6% female) had a median MinHR of 59 [52-68] bpm, with 248 deaths (10.94%). RCS analysis revealed a U-shaped association (P for nonlinear =0.001) with 59 bpm as the inflection point. MinHR ≥59 bpm independently predicted higher mortality after full adjustment (HR=1.84, 95%CI:1.31-2.60; P<0.001). This association was pronounced in non-hypertensive patients (HR=1.50, 95%CI:1.08-2.08; P=0.015). A U-shaped association exists between 24-hour MinHR and 1-month mortality in TBI patients, with 59 bpm as the critical threshold. MinHR ≥59 bpm independently predicts increased mortality. These findings support using 59 bpm as an alert threshold for early intervention.

Source: Surgery in Practice and Science

DOI: 10.1016/j.sipas.2025.100312

Authors: Xin Li, Meng Han, Xiaoliang Wang, Wenjuan Lang, Kai Shi

Institution: Qingdao Municipal Hospital

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,020