Work

Enhanced extraction of human interstitial fluid using microneedles and laser-induced fluid recruitment

Year: 2025

Type: article

Abstract: ISF extraction method involving laser pretreatment of skin to increase water content, microneedle puncture of skin to create pathways for ISF flow, and suction to drive ISF flow. This method yielded ISF volumes of up to 55 μL in human subjects, an 8-fold increase compared to extraction without laser and 4-fold increase in ISF volume per microneedle compared to prior studies. Overall, microneedles with laser-induced fluid recruitment provide a new mechanism to increase ISF sampling from skin, advancing the study of ISF biomarkers and ISF-based diagnostics.

Source: iScience

DOI: 10.1016/j.isci.2025.113741

Authors: Juan L. Mena-Lapaix, Chizimuzo Chibuko, Min Htat Kyaw, Mark R. Prausnitz

Institution: Georgia Institute of Technology

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240